Structure of PDB 6xnz Chain A Binding Site BS02

Receptor Information
>6xnz Chain A (length=550) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPLHALRNAEK
VLLPGYHPFEWQPPLKNVSSRTDVGIIDGLSGLASSVDEYPVDTIAKRFR
YDSALVSALMDMEEDILEGMRSQDLDDYLNGPFTVVVKESCDGMGDVSEK
HGSGPAVPEKAVRFSFTVMRITIEHGSQNVKVFEEPKPNSVLCCKPLCLM
LADESDHETLTAILSPLIAEREAMKSSELTLEMGGIPRTFKFIFRGTGYD
EKLVREVEGLEASGSVYICTLCDTTRLEASQNLVFHSITRSHAENLQRYE
VWRSNPYHESVEELRDRVKGVSAKPFIETVPSIDALHCDIGNAAEFYKIF
QLEIGEVYKHPNASKEERKRWQATLDKHLRKRMNLKPIMMMNGNFARKLM
TQETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSCPAKECPESLCQ
YSFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWAS
EGNESGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNA
Ligand information
Receptor-Ligand Complex Structure
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PDB6xnz Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		D600 K618 E662 D708 E709 K710 S721 G722 R734 H795 E803 K823 R826 M848 R927 K931 I932 T933 N934 Y935 E962
Binding residue
(residue number reindexed from 1)		D142 K160 E204 D250 E251 K252 S263 G264 R276 H337 E345 K365 R368 M390 R469 K473 I474 T475 N476 Y477 E504
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0033151 V(D)J recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6xnz, PDBe:6xnz, PDBj:6xnz
PDBsum6xnz
PubMed32945578
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

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