Structure of PDB 6xnx Chain A Binding Site BS02

Receptor Information
>6xnx Chain A (length=549) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPLHALRNAEKV
LLPGYHPFEWQPPLKNVSSRTDVGIIDGLSGLASSVDEYPVDTIAKRFRY
DSALVSALMDMEEDILEGMRSQDLDDYLNGPFTVVVKESCDGMGDVSEKH
GSGPAVPEKAVRFSFTVMRITIEHGSQNVKVFEEPKPNSVLCCKPLCLML
ADESDHETLTAILSPLIAEREAMKSSELTLEMGGIPRTFKFIFRGTGYDE
KLVREVEGLEASGSVYICTLCDTTRLEASQNLVFHSITRSHAENLQRYEV
WRSNPYHESVEELRDRVKGVSAKPFIETVPSIDALHCDIGNAAEFYKIFQ
LEIGEVYKHPNASKEERKRWQATLDKHLRKRMNLKPIMMMNGNFARKLMT
QETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSCPAKECPESLCQY
SFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWASE
GNESGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xnx Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		M602 G603 D604 L794 H795 M847 M848 N850 G851 N852 E959 E962 S963 N965 K966 R969
Binding residue
(residue number reindexed from 1)		M143 G144 D145 L335 H336 M388 M389 N391 G392 N393 E500 E503 S504 N506 K507 R510
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0033151 V(D)J recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6xnx, PDBe:6xnx, PDBj:6xnx
PDBsum6xnx
PubMed32945578
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

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