Structure of PDB 6xms Chain A Binding Site BS02

Receptor Information
>6xms Chain A (length=1091) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGT
LVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIV
EIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKC
KGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWL
LDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKK
WVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTP
LLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDG
GALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEALMFILFLLIFAVIA
SWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALA
KFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIR
HLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERK
NSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRER
LSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLI
FHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLI
LDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYAL
NALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTND
VGALKQAHVGIALLNGTEEGLKKLGEQRRLEALKLGDASCAAPFTSKLAN
VSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQ
ATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHI
ATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVN
YQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDD
FKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain6xms Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xms The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D487 T489 T697 G698
Binding residue
(residue number reindexed from 1)		D474 T476 T677 G678
Annotation score1
Enzymatic activity
Enzyme Commision number 7.4.2.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015662 P-type ion transporter activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0140358 P-type transmembrane transporter activity
GO:0140567 membrane protein dislocase activity
Biological Process
GO:0006874 intracellular calcium ion homeostasis
GO:0015031 protein transport
GO:0030026 intracellular manganese ion homeostasis
GO:0034214 protein hexamerization
GO:0043335 protein unfolding
GO:0055085 transmembrane transport
GO:0055092 sterol homeostasis
GO:0098655 monoatomic cation transmembrane transport
GO:0140569 extraction of mislocalized protein from ER membrane
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005801 cis-Golgi network
GO:0016020 membrane

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6xms, PDBe:6xms, PDBj:6xms
PDBsum6xms
PubMed32973005
UniProtP39986|SPF1_YEAST Endoplasmic reticulum transmembrane helix translocase (Gene Name=SPF1)

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