Structure of PDB 6xlh Chain A Binding Site BS02

Receptor Information
>6xlh Chain A (length=607) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSD
PKQLETEPDLFIRITPKPEEKVLEIRDSGIGMTKAELINNLGTIAKSGTK
AFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNEDEQYIWESNA
GGSFTVTLDEVNERIGRGTVLRLFLKDDQLEYLEEKRIKEVIKRHSEFVA
YPIQLLVTKVQELEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPL
YVKHFSVEGQLEFRAILFIPKRAPFNNIKLYVRRVFITDEAEDLIPEWLS
FVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQ
FDKFYSAFAKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTR
MPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQL
KEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKDILGDQVE
KVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRSKKTFEISPKSPII
KELKKRVDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLI
SLGLNID
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6xlh Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6xlh Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
Resolution2.83 Å
Binding residue
(original residue number in PDB)		E33 N37
Binding residue
(residue number reindexed from 1)		E31 N35
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0000723 telomere maintenance
GO:0006457 protein folding
GO:0034605 cellular response to heat
GO:0043248 proteasome assembly
GO:0050821 protein stabilization
GO:0070482 response to oxygen levels
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xlh, PDBe:6xlh, PDBj:6xlh
PDBsum6xlh
PubMed
UniProtP15108|HSC82_YEAST ATP-dependent molecular chaperone HSC82 (Gene Name=HSC82)

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