Structure of PDB 6xeo Chain A Binding Site BS02

Receptor Information
>6xeo Chain A (length=1118) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALR
LHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRG
VLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVD
QVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLE
EVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLP
AGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFE
NRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLG
FQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLAR
IKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERI
GQPVVHLEHGVGRYAGMTTLEAGGITGEYLMLTYANDAKLYVPVSSLHLI
SRYAGGAEENAPLHKLGGDAWSRARQKAAEKVRDVAAELLDIYAQRAAKE
GFAFKHDREQYQLFCDSFPFETTPDQAQAINAVLSDMCQPLAMDRLVCGD
VGFGKTEVAMRAAFLAVDNHKQVAVLVPTTLLAQQHYDNFRDRFANWPVR
IEMISRFRSAKEQTQILAEVAEGKIDILIGTHKLLQSDVKFKDLGLLIVD
EEHRFGVRHKERIKAMRANVDILTLTATPIPRTLNMAMSGMRDLSIIATP
PARRLAVKTFVREYDSMVVREAILREILRGGQVYYLYNDVENIQKAAERL
AELVPEARIAIGHGQMRERELERVMNDFHHQRFNVLVCTTIIETGIDIPT
ANTIIIERADHFGLAQLHQLRGRVGRSHHQAYAWLLTPHPKAMTTDAQKR
LEAIASLEDLGAGFALATHDLEIRGAGELLGEEQSGSMETIGFSLYMELL
ENAVDALKAGREPSLEDLTSQQTEVELRMPSLLPDDFIPDVNTRLSFYKR
IASAKTENELEEIKVELIDRFGLLPDPARTLLDIARLRQQAQKLGIRKLE
GNEKGGVIEFAEKNHVNPAWLIGLLQKQPQHYRLDGPTRLKFIQDLSERK
TRIEWVRQFMRELEENAI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xeo Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd.
Resolution5.5 Å
Binding residue
(original residue number in PDB)		R733 F734 R737 R848 D925
Binding residue
(residue number reindexed from 1)		R704 F705 R708 R819 D896
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0043175 RNA polymerase core enzyme binding
Biological Process
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xeo, PDBe:6xeo, PDBj:6xeo
PDBsum6xeo
PubMed32719356
UniProtP30958|MFD_ECOLI Transcription-repair-coupling factor (Gene Name=mfd)

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