Structure of PDB 6xbu Chain A Binding Site BS02

Receptor Information
>6xbu Chain A (length=605) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRGGDDTLVVGLAV
CWGGRDAYYFSLLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYK
ILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEG
METSQGIQSLGLSEHSGRYRASVESILIFNSMNQLNSLLQKENLQDVFRK
VEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQSFTSSDDIA
EVLFLSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNP
FLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMGMPFSISMRHAF
VPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKM
IEPESVGDDDRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKS
RYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQA
INTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDCPIRGG
FFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASW
GELKD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xbu Pol theta reverse transcribes RNA and promotes RNA-templated DNA repair.
Resolution3.29 Å
Binding residue
(original residue number in PDB)		K2209 T2237 A2238 N2251 Y2391 M2393 G2394 K2396 S2397 H2463 R2466 Q2467 N2470
Binding residue
(residue number reindexed from 1)		K287 T315 A316 N329 Y423 M425 G426 K428 S429 H495 R498 Q499 N502
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6xbu, PDBe:6xbu, PDBj:6xbu
PDBsum6xbu
PubMed34117057
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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