Structure of PDB 6x91 Chain A Binding Site BS02

Receptor Information
>6x91 Chain A (length=592) Species: 9606,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELVKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNSSSRRRIEPWEFDVFYDPRELRKEACLLYEIKW
GASSKIWRSSGKNTTNHVAVNFIKKFTSERDFHPSTSCSITWFLSWSPCW
ECSQAIREFLSRHPGVTLVIYVARLFAHMDQQNRQGLRDLVNSGVTIQIM
RDSEYYHCWRNFVNYPPGDEAHWPQYPPAWMMLYALELHCIILSLPPCLK
ISRRAQNHLTAFRLHLQNCHYQTIPPHILLATGLIHPSVAWR
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain6x91 Chain I Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x91 The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
Resolution3.51 Å
Binding residue
(original residue number in PDB)		W63 D66 R67 Y156 W341
Binding residue
(residue number reindexed from 1)		W62 D65 R66 Y155 W340
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.36: mRNA(cytosine(6666)) deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0016787 hydrolase activity
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0046872 metal ion binding
GO:1901982 maltose binding
Biological Process
GO:0006397 mRNA processing
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0010332 response to gamma radiation
GO:0015768 maltose transport
GO:0016554 cytidine to uridine editing
GO:0016556 mRNA modification
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042127 regulation of cell population proliferation
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042953 lipoprotein transport
GO:0042956 maltodextrin transmembrane transport
GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation
GO:0048255 mRNA stabilization
GO:0051649 establishment of localization in cell
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
GO:0090209 negative regulation of triglyceride metabolic process
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0030895 apolipoprotein B mRNA editing enzyme complex
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0045293 mRNA editing complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x91, PDBe:6x91, PDBj:6x91
PDBsum6x91
PubMed33094286
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
P41238

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