Structure of PDB 6x6e Chain A Binding Site BS02

Receptor Information

>6x6e Chain A (length=73) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKI
RRKNCPACRYRKCLQAGMNLEAR

Ligand information

>6x6e Chain D (length=18) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tcagaacgctccgttctg

Receptor-Ligand Complex Structure

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PDB	6x6e Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	G439 S440 F444 R447 R470 K471 R477
Binding residue (residue number reindexed from 1)	G21 S22 F26 R29 R52 K53 R59

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Biological Process

External links

PDB	RCSB:6x6e, PDBe:6x6e, PDBj:6x6e
PDBsum	6x6e
PubMed	34289059
UniProt	P04150\|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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