Structure of PDB 6x50 Chain A Binding Site BS02

Receptor Information
>6x50 Chain A (length=1143) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALR
LHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRG
VLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVD
QVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLE
EVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLP
AGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFE
NRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLG
FQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLAR
IKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERV
ARRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGGI
TGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRAR
QKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTPD
QAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVAV
LVPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGKI
DILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILTL
TATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAILR
EILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERVM
NDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRVG
RSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIRG
AGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTEV
ELRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLLP
DPARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGLL
QKQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAI
Ligand information
>6x50 Chain Q (length=49) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accgctgcaaggaataggatacttgcgggctagatggcggcgaataccc
Receptor-Ligand Complex Structure
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PDB6x50 Structural basis for transcription complex disruption by the Mfd translocase.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R733 R737 I759 R846 T923 R929 R953
Binding residue
(residue number reindexed from 1)		R729 R733 I755 R842 T919 R925 R949
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0043175 RNA polymerase core enzyme binding
Biological Process
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6x50, PDBe:6x50, PDBj:6x50
PDBsum6x50
PubMed33480355
UniProtP30958|MFD_ECOLI Transcription-repair-coupling factor (Gene Name=mfd)

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