Structure of PDB 6x43 Chain A Binding Site BS02

Receptor Information
>6x43 Chain A (length=1144) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QYRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNAL
RLHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQR
GVLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHV
DQVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTL
EEVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTL
PAGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARF
ENRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANL
GFQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLA
RIKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGER
VARRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGG
ITGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRA
RQKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTP
DQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVA
VLVPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGK
IDILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILT
LTATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAIL
REILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERV
MNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRV
GRSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIR
GAGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTE
VELRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLL
PDPARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGL
LQKQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAI
Ligand information
>6x43 Chain Q (length=49) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accgctgcaaggaataggatacttgcgggctatatggcggcgaataccc
Receptor-Ligand Complex Structure
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PDB6x43 Structural basis for transcription complex disruption by the Mfd translocase.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		G735 I759 R929 R953 E961
Binding residue
(residue number reindexed from 1)		G732 I756 R926 R950 E958
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0043175 RNA polymerase core enzyme binding
Biological Process
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6x43, PDBe:6x43, PDBj:6x43
PDBsum6x43
PubMed33480355
UniProtP30958|MFD_ECOLI Transcription-repair-coupling factor (Gene Name=mfd)

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