Structure of PDB 6x26 Chain A Binding Site BS02

Receptor Information
>6x26 Chain A (length=1142) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALRL
HDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRGV
LIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVDQ
VMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLEE
VEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLPA
GIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFEN
RGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLGF
QKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLARI
KIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERVA
RRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGGIT
GEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRARQ
KAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTPDQ
AQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVAVL
VPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGKID
ILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILTLT
ATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAILRE
ILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERVMN
DFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRVGR
SHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIRGA
GELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTEVE
LRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLLPD
PARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGLLQ
KQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAI
Ligand information
>6x26 Chain Q (length=49) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accgctgcaaggaataggatacttgcgggctatatggcggcgaataccc
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6x26 Structural basis for transcription complex disruption by the Mfd translocase.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		K690 R733 R737 H738 R846 H890 G892 Q895 E961
Binding residue
(residue number reindexed from 1)		K685 R728 R732 H733 R841 H885 G887 Q890 E956
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0043175 RNA polymerase core enzyme binding
Biological Process
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990391 DNA repair complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x26, PDBe:6x26, PDBj:6x26
PDBsum6x26
PubMed33480355
UniProtP30958|MFD_ECOLI Transcription-repair-coupling factor (Gene Name=mfd)

[Back to BioLiP]