Structure of PDB 6wu7 Chain A Binding Site BS02

Receptor Information
>6wu7 Chain A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QTVFTHEQLEAYQDCTFFTRKEIMRLFYRYQDLAPQLVPLDYTTCPDVKV
PYELIGSMPELKDNPFRQRIAQVFSEDGDGHMTLDNFLDMFSVMSEMAPR
DLKAYYAFKIYDFNNDDYICAWDLEQTVTKLTRGELSAEEVSLVCQHVLD
EADGDHDGRLSLEDFQNMILRAPDFLSTFHI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6wu7 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wu7 CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.
Resolution1.84 Å
Binding residue
(original residue number in PDB)		D157 D159 D161 R163 D168
Binding residue
(residue number reindexed from 1)		D153 D155 D157 R159 D164
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0055074 calcium ion homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:6wu7, PDBe:6wu7, PDBj:6wu7
PDBsum6wu7
PubMed34089643
UniProtQ96Q77|CIB3_HUMAN Calcium and integrin-binding family member 3 (Gene Name=CIB3)

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