Structure of PDB 6wb2 Chain A Binding Site BS02

Receptor Information
>6wb2 Chain A (length=540) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGP
ENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKK
KKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPGIRYQYNVLPQGWKGSPAI
FQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHL
LRWGLTTPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDICKLVGKLNWA
SQIYPGIKVRQLSKLLRGTKALTEVIPTEEAELELAENREILKEPVHGVY
YDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQL
TEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVN
TPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVP
LTNTTNQKTQLQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELV
NQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRK
Ligand information
>6wb2 Chain D (length=42) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggauguccaggguucaagucccuguucgggcgccactg
<<<<<<<<>>>>.>>>>.........................
Receptor-Ligand Complex Structure
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PDB6wb2 Distinct Conformational States Underlie Pausing during Initiation of HIV-1 Reverse Transcription.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		Q151 H539
Binding residue
(residue number reindexed from 1)		Q142 H521
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6wb2, PDBe:6wb2, PDBj:6wb2
PDBsum6wb2
PubMed32512005
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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