Structure of PDB 6w8d Chain A Binding Site BS02

Receptor Information
>6w8d Chain A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQ
GKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTG
RLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPV
MIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFS
KVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVS
NMSHLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w8d Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Resolution2.598 Å
Binding residue
(original residue number in PDB)		S708 C710 N711 S714 I715 V716 N717 P718 E756 V758 R792 R831 T832 T835 R836 G843 K844 G890 R891
Binding residue
(residue number reindexed from 1)		S80 C82 N83 S86 I87 V88 N89 P90 E128 V130 R164 R203 T204 T207 R208 G215 K216 G262 R263
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6w8d, PDBe:6w8d, PDBj:6w8d
PDBsum6w8d
PubMed32385248
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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