Structure of PDB 6w25 Chain A Binding Site BS02

Receptor Information
>6w25 Chain A (length=468) Species: 9606,272844 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLFVSPVVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADML
VSVSLGFETIVITLLNSTDAQSFTVNIDNVIDSVICASLLASICSLLSIA
VDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVI
ICLITMFFTMLALMASLYVHMFLMARLHGIDCSFWNESYLTGSRDERKKS
LLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIII
GKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFE
PFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILK
ALELSRSDLSKFRENCKKRAMSFSRQGANMKGAITLTILIGVFVVCWAPF
FLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIINPLIYALRSQELRK
TFKEIICCYEFLEVLFQG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6w25 Chain A Residue 2101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6w25 Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		E100 D122 D126 H264
Binding residue
(residue number reindexed from 1)		E58 D78 D82 H403
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w25, PDBe:6w25, PDBj:6w25
PDBsum6w25
PubMed32327598
UniProtP32245|MC4R_HUMAN Melanocortin receptor 4 (Gene Name=MC4R);
Q9V2J8

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