Structure of PDB 6vzr Chain A Binding Site BS02

Receptor Information
>6vzr Chain A (length=400) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVME
MKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADW
GDLQTYSRTRKNKTYICKPDSGARGRGIFITRSVKEIKPGEDMICQLYIS
KPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLD
EICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRG
IEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPW
LLEVNISPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRG
RFLQQEIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFF
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6vzr Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6vzr Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K125 I172 K174 A179 R180 G181 I184 Q202 Y204 I205 K215 D217 T263 N264 L358 E359
Binding residue
(residue number reindexed from 1)		K69 I116 K118 A123 R124 G125 I128 Q146 Y148 I149 K159 D161 T207 N208 L302 E303
Annotation score5
Enzymatic activity
Enzyme Commision number 6.3.2.-
Gene Ontology
Biological Process
GO:0036211 protein modification process

View graph for
Biological Process
External links
PDB RCSB:6vzr, PDBe:6vzr, PDBj:6vzr
PDBsum6vzr
PubMed32747782
UniProtA4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)

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