Structure of PDB 6vgd Chain A Binding Site BS02

Receptor Information
>6vgd Chain A (length=98) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6vgd Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		Q282 L283 W321 K325 K327 M330 K334 R337 A338 Y341 Y342
Binding residue
(residue number reindexed from 1)		Q8 L9 W47 K51 K53 M56 K60 R63 A64 Y67 Y68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6vgd, PDBe:6vgd, PDBj:6vgd
PDBsum6vgd
PubMed33275876
UniProtQ01543|FLI1_HUMAN Friend leukemia integration 1 transcription factor (Gene Name=FLI1)

[Back to BioLiP]