Structure of PDB 6vg8 Chain A Binding Site BS02

Receptor Information
>6vg8 Chain A (length=96) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQ
Ligand information
Receptor-Ligand Complex Structure
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PDB6vg8 Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
Resolution4.31 Å
Binding residue
(original residue number in PDB)		Q282 L283 W321 K325 K327 M330 K334 R337 Y342
Binding residue
(residue number reindexed from 1)		Q8 L9 W47 K51 K53 M56 K60 R63 Y68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:6vg8, PDBe:6vg8, PDBj:6vg8
PDBsum6vg8
PubMed33275876
UniProtQ01543|FLI1_HUMAN Friend leukemia integration 1 transcription factor (Gene Name=FLI1)

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