Structure of PDB 6vfp Chain A Binding Site BS02

Receptor Information
>6vfp Chain A (length=439) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDI
FTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV
QDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ
AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSP
PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSD
QGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVL
AKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDV
AEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFL
QTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6vfp Chain A Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vfp Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered delta-Protocadherins.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E122 D182 E184 D218
Binding residue
(residue number reindexed from 1)		E121 D181 E183 D217
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vfp, PDBe:6vfp, PDBj:6vfp
PDBsum6vfp
PubMed32101743
UniProtQ08174|PCDH1_HUMAN Protocadherin-1 (Gene Name=PCDH1)

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