Structure of PDB 6vff Chain A Binding Site BS02

Receptor Information
>6vff Chain A (length=382) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKV
ISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNK
DDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPA
DRHPNRKARGQLRTKIESGQGTIPVRSNASIQTWDGVLQGERLLTMSCSD
KIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIE
DLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGK
DELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEY
QAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>6vff Chain D (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cguagcuaucagagccccccagcaucgcgagc
................................
Receptor-Ligand Complex Structure
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PDB6vff Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		I456 F457 R474 R477 R481 G487 Q488 I491 P492 R510
Binding residue
(residue number reindexed from 1)		I138 F139 R156 R159 R163 G169 Q170 I173 P174 R192
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:6vff, PDBe:6vff, PDBj:6vff
PDBsum6vff
PubMed32597966
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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