Structure of PDB 6vf8 Chain A Binding Site BS02

Receptor Information

>6vf8 Chain A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

WMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVL
KALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQT
MKLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDL
STPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLIT
HPKEGQEAGLLPRVMCRLQDQGLILYHQAFERSFCIFRLPQPGSWKAVRV
DLVVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQK
TFFQAASEEDIFRHLGLEYLPPEQRNA

Ligand information

>6vf8 Chain P (length=4) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgta

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6vf8 DNA Polymerase Mu, 8-oxorGTP:Ct Pre-Catalytic Ternary Complex, 20 mM Ca2+ (120 min)
Resolution	1.7 Å
Binding residue (original residue number in PDB)	G245 V246 G247 T250 H329 F389 R416
Binding residue (residue number reindexed from 1)	G109 V110 G111 T114 H193 F234 R249

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6vf8, PDBe:6vf8, PDBj:6vf8
PDBsum	6vf8
PubMed
UniProt	Q9NP87\|DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (Gene Name=POLM)

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