Structure of PDB 6vbg Chain A Binding Site BS02

Receptor Information
>6vbg Chain A (length=396) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFA
AISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQ
YNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVG
WALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTANHSAFSLKLA
LELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWY
VTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSAL
EVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMI
FMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLL
Ligand information
Ligand IDGAL
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-FPRJBGLDSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
FormulaC6 H12 O6
Namebeta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose
ChEMBLCHEMBL300520
DrugBank
ZINCZINC000002597049
PDB chain6vbg Chain E Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vbg Diversity in kinetics correlated with structure in nano body-stabilized LacY.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R144 C148 W151 E269 H322
Binding residue
(residue number reindexed from 1)		R144 C148 W151 E256 H309
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005351 carbohydrate:proton symporter activity
GO:0005515 protein binding
GO:0015293 symporter activity
GO:0015528 lactose:proton symporter activity
GO:0022857 transmembrane transporter activity
GO:0030395 lactose binding
Biological Process
GO:0008643 carbohydrate transport
GO:0015767 lactose transport
GO:0034219 carbohydrate transmembrane transport
GO:0055085 transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vbg, PDBe:6vbg, PDBj:6vbg
PDBsum6vbg
PubMed32380514
UniProtP02920|LACY_ECOLI Lactose permease (Gene Name=lacY)

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