Structure of PDB 6v0t Chain A Binding Site BS02

Receptor Information
>6v0t Chain A (length=402) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPPQVNSILKANEYSFKVPEFDGKNVSSVLGFDSNQLPANAPIEDRRSAA
TCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV
ESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNIDVKEAL
INAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHV
ANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNEREVERLKLEHPKNEAKS
VVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPKFIPPNYYTPPYL
TAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMDQNAA
THLIRHAVGNNEFGAERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGA
YQ
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6v0t Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v0t Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D73 D347 D445
Binding residue
(residue number reindexed from 1)		D64 D323 D384
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.43: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase.
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
GO:0043169 cation binding
Biological Process
GO:0006470 protein dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6v0t, PDBe:6v0t, PDBj:6v0t
PDBsum6v0t
PubMed32627744
UniProtP35816|PDP1_BOVIN [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (Gene Name=PDP1)

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