Structure of PDB 6usq Chain A Binding Site BS02

Receptor Information

>6usq Chain A (length=596) Species: 7070 (Tribolium castaneum)

MVHYYRLSLKSRQKAPKIVNSKYNSILNIALKNFRLCKKHKTKKPVQILA
LLQEIIPKSYFGTTTNLKRFYKVVEKILTQSSFECIHLSVLHKCYDYDAI
PWLQNVEPNLRPKLLLKHNLFLLDNIVKPIIAFYYKPIKTLNGHEIKFIR
KEEYISFESKVFHKLKKMKYLVEVQDEVKPRGVLNIIPKQDNFRAIVSIF
PDSARKPFFKLLTSKIYKVLEEKYKTSGSLYTCWSEFTQKTQGQIYGIKV
DIRDAAGNVKIPVLCKLIQSIPTHLLDSEKKNFIVDHISNQFVAFRRKIY
KWNHGLLQGDPLSGCLCELYMAFMDRLYFSNLDKDAFIHRTVDDYFFCSP
HPHKVYDFELLIKGVYQVNPTKTRTNLPTHRHPQDEIPYCGKIFNLTTRQ
VRTLYKLPPNYEIRHKFKLWNFNNQISDDNPARFLQKAMDFPFICNSFTK
FEFNTVFNDQRTVFANFYDAMICVAYKFDAAMMALRTSFLVNDFGFIWLV
LSSTVRAYASRAFKKIVTYKGGKYRKVTFQCLKSIAWRAFLAVLKRRTEI
YKGLIDRIKSREKLTMKFHDGEVDASYFCKLPEKFRFVKINRKASI

Ligand information

>6usq Chain F (length=16)

cugaccugacctgacc

................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6usq Mechanisms of nucleotide selection by telomerase.
• Resolution: 3.62 Å
• Binding residue (original residue number in PDB): P442 C445 R511
• Binding residue (residue number reindexed from 1): P442 C445 R511

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:6usq, PDBe:6usq, PDBj:6usq
• PDBsum: 6usq
• PubMed: 32501800
• UniProt: Q0QHL8