Structure of PDB 6uqi Chain A Binding Site BS02

Receptor Information

>6uqi Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVAYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS

Ligand information

>6uqi Chain P (length=8) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agcgtcat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6uqi Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*)
Resolution	2.5 Å
Binding residue (original residue number in PDB)	R61 S113 E116 K224 S257 G259 G260 K261 L262 R377 L381 R382 R383
Binding residue (residue number reindexed from 1)	R64 S116 E119 K222 S255 G257 G258 K259 L260 R375 L379 R380 R381

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:6uqi, PDBe:6uqi, PDBj:6uqi
PDBsum	6uqi
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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