Structure of PDB 6up4 Chain A Binding Site BS02

Receptor Information
>6up4 Chain A (length=814) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSYIDRDTEYLLQENEPNLSLDQHLLEDLQRKKTDPRYIEMQRFRKKLPS
YGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRI
VCTQPRRISAISVAERVATERAESCGNGNSTGYQIRLQSRLPRKQGSILY
CTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSD
LKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVP
DQKQFKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELRTRYSASTVDVLQ
MMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVM
FKSDKFLIIPLQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGK
IKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRAS
LLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVVLSI
KHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTI
AASLSFKDPFVIPLGKEKIADARRKELAKETRSDHLTVVNAFEGWEEAKR
RGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRSPKDPKA
NINSDNEKIIKAVICAGLYPKVAKIRLNLKMVKVHTKSDGLVSIHPKSVN
VEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKDQ
EIIAVDEWIVFQSPERIAHLVKGLRKELDSLLQEKIESPHPVDWDDTKSR
DCAVLSAILDLIKT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6up4 Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6up4 Function of Auxiliary Domains of the DEAH/RHA Helicase DHX36 in RNA Remodeling.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T229 E327
Binding residue
(residue number reindexed from 1)		T78 E176
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6up4, PDBe:6up4, PDBj:6up4
PDBsum6up4
PubMed32087197
UniProtQ8VHK9|DHX36_MOUSE ATP-dependent DNA/RNA helicase DHX36 (Gene Name=Dhx36)

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