Structure of PDB 6ukn Chain A Binding Site BS02

Receptor Information
>6ukn Chain A (length=536) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCCTCTML
TAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY
ILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVV
FVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLA
NRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQG
IPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDI
MTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIY
LSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTC
GAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICE
TGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHW
TLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYI
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain6ukn Chain A Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ukn Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		G433 I434 M435 Y589
Binding residue
(residue number reindexed from 1)		G317 I318 M319 Y473
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0015377 chloride:monoatomic cation symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071333 cellular response to glucose stimulus
GO:0071805 potassium ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ukn, PDBe:6ukn, PDBj:6ukn
PDBsum6ukn
PubMed32286222
UniProtQ9WVL3|S12A7_MOUSE Solute carrier family 12 member 7 (Gene Name=Slc12a7)

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