Structure of PDB 6uka Chain A Binding Site BS02

Receptor Information
>6uka Chain A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRT
VNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPE
VCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIH
AVRYLECSALQQDGVKEVFAEAVRAVL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6uka Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6uka Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T17 T35
Binding residue
(residue number reindexed from 1)		T17 T35
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019901 protein kinase binding
Biological Process
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007264 small GTPase-mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0016601 Rac protein signal transduction
GO:0030036 actin cytoskeleton organization
GO:0030865 cortical cytoskeleton organization
GO:0032956 regulation of actin cytoskeleton organization
GO:0045893 positive regulation of DNA-templated transcription
GO:0060326 cell chemotaxis
GO:0090630 activation of GTPase activity
GO:0150052 regulation of postsynapse assembly
GO:1900027 regulation of ruffle assembly
GO:1903078 positive regulation of protein localization to plasma membrane
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030667 secretory granule membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0070062 extracellular exosome
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uka, PDBe:6uka, PDBj:6uka
PDBsum6uka
PubMed32651375
UniProtP84095|RHOG_HUMAN Rho-related GTP-binding protein RhoG (Gene Name=RHOG)

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