Structure of PDB 6u6y Chain A Binding Site BS02
Receptor Information
>6u6y Chain A (length=434) Species:
9606
(Homo sapiens) [
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MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVAKWDYFARDCH
HLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTK
LTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRE
DYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMHVSFYCKTAPNRAIEQ
LIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQ
Ligand information
>6u6y Chain H (length=4) [
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cgcc
....
Receptor-Ligand Complex Structure
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PDB
6u6y
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Resolution
2.47 Å
Binding residue
(original residue number in PDB)
K116 V117 I118 H125 D137
Binding residue
(residue number reindexed from 1)
K2 V3 I4 H11 D23
Enzymatic activity
Enzyme Commision number
3.1.5.-
External links
PDB
RCSB:6u6y
,
PDBe:6u6y
,
PDBj:6u6y
PDBsum
6u6y
PubMed
33531504
UniProt
Q9Y3Z3
|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)
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