Structure of PDB 6u2z Chain A Binding Site BS02

Receptor Information

>6u2z Chain A (length=266) Species: 522373 (Stenotrophomonas maltophilia K279a)

EAPLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVL
LDGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTG
AHVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIA
FTAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPR
LIEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYAD
AAEKKFDAQLARETAG

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 6u2z Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6u2z Crystal Structure of the metallo-beta-lactamase L1 from Stenotrophomonas maltophilia in the complex with the hydrolyzed moxalactam and two copper ions
• Resolution: 2.38 Å
• Binding residue (original residue number in PDB): D109 H110 H246
• Binding residue (residue number reindexed from 1): D87 H88 H224
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H105 H107 D109 H110 H181 Y212 H246
• Catalytic site (residue number reindexed from 1): H83 H85 D87 H88 H159 Y190 H224
• Enzyme Commision number: 3.5.2.6: beta-lactamase.

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008800 beta-lactamase activity

Biological Process

• GO:0017001 antibiotic catabolic process

External links

• PDB: RCSB:6u2z, PDBe:6u2z, PDBj:6u2z
• PDBsum: 6u2z
• UniProt: B2FTM1