Structure of PDB 6tp5 Chain A Binding Site BS02

Receptor Information

>6tp5 Chain A (length=370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEEC
RLIIHLAQMKGLQRSQILPTEEYEEQVSQLDLFRLLDQNRDGHLQLREVL
AQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYM
RSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELS
EPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMT
VLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRV
KPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVD
PSRARQALFQQEMARLAREG

Ligand information

InChI=1S/Fe/q+2

CWYNVVGOOAEACU-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Fe+2]
CACTVS 3.341	[Fe++]

Formula

Name

FE (II) ION

PDB chain

6tp5 Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	6tp5 Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.
Resolution	2.25 Å
Binding residue (original residue number in PDB)	H328 D330 H441
Binding residue (residue number reindexed from 1)	H217 D219 H330
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.29: hypoxia-inducible factor-proline dioxygenase.

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418	L-ascorbic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:6tp5, PDBe:6tp5, PDBj:6tp5
PDBsum	6tp5
PubMed	33334883
UniProt	Q9NXG6\|P4HTM_HUMAN Transmembrane prolyl 4-hydroxylase (Gene Name=P4HTM)

[Back to BioLiP]