Structure of PDB 6th4 Chain A Binding Site BS02

Receptor Information
>6th4 Chain A (length=428) Species: 9940 (Ovis aries) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSGDDSFNTFFSET
GAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARG
HYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMER
LSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDN
EAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQ
TNLVPYPRIHFPLATYAPVISAEHEQLSVAEITNACFEPANQMVKCDPRH
GKYMACCLLYRGDVVPKDVNAAIATIKTIQFVDWCPTGFKVGINYQPPTV
VPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEG
MEEGEFSEAREDMAALEKDYEEVGVDSV
Ligand information
Ligand IDN9B
InChIInChI=1S/C20H20O5/c1-11-8-12-9-17(23-3)19(24-4)20(25-5)18(12)13-6-7-16(22-2)15(21)10-14(11)13/h6-7,9-10H,1,8H2,2-5H3
InChIKeyLWZCIQWVGDAJGE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385COC1=CC=C2C(=CC1=O)C(=C)Cc3cc(OC)c(OC)c(OC)c23
OpenEye OEToolkits 2.0.7COc1cc2c(c(c1OC)OC)C3=CC=C(C(=O)C=C3C(=C)C2)OC
FormulaC20 H20 O5
Name1,2,3,9-tetramethoxy-6-methylidene-5~{H}-cyclohepta[a]naphthalen-8-one
ChEMBLCHEMBL4748438
DrugBank
ZINC
PDB chain6th4 Chain B Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6th4 B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner
Resolution2.121 Å
Binding residue
(original residue number in PDB)		A180 V181
Binding residue
(residue number reindexed from 1)		A174 V175
Annotation score1
Gene Ontology
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UnboundLocalError		Python 3.6.8: /usr/bin/python3
Sat Feb 22 21:53:25 2025

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()
   1435     title=pdb2title(pdbid)
   1436     if bs.startswith("BS"):
=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)
   1438     else:
   1439         if lig3:
pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6th4', asym_id = 'A', bs = 'BS02', title = 'B-nor-methylene Colchicinoid PT-100 Selectively ...ntrinsic Pathway in a Caspase-Independent Manner '
 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6th4', asym_id='A', bs='BS02', title='B-nor-methylene Colchicinoid PT-100 Selectively ...ntrinsic Pathway in a Caspase-Independent Manner ')
   1295         display_ec(ec,csaOrig,csaRenu)
   1296     if go:
=> 1297         display_go(go,uniprot,pdbid,asym_id)
   1298     return pubmed,uniprot
   1299 
global display_go = <function display_go>, go = '0005200,0005525,0005874,0007017', uniprot = '', pdbid = '6th4', asym_id = 'A'
 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005200,0005525,0005874,0007017', uniprot='', pdbid='6th4', asym_id='A')
    480         '''.replace("$namespace_link",namespace_link
    481           ).replace("$namespace",namespace
=>  482           ).replace("$uniprot",u
    483         ))
    484         for l,(term,name) in enumerate(go2aspect[Aspect]):
u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>