Structure of PDB 6t66 Chain A Binding Site BS02

Receptor Information

>6t66 Chain A (length=440) Species: 666 (Vibrio cholerae)

KVPPHSLEAEQSVIGGLLLDNERWDTVSEHVMTQDFYSRPHRLIFDGVKS
ILEAGKPLDLITLSEYLEQREQLEDVGGFAYLADLAKNTPSAANINAYAE
IVAERALVRNLIGVANEIADAGYDPQGRNAEDLLDLAESKVFAIAEARTS
ENEGPKNVDSILERTLERIELLYKTPQDGVTGVNTGFTDLNKKTAGLQGS
DLIIVAARPSMGKTTFAMNLCENAAMEQDKPVLIFSLEMPAEQIMMRMLA
SLSRVDQTKIRTGQLDDEDWARISSTMGILMEKKNMYIDDSSGLTPTEVR
SRARRIAREHGGLSLIMVDYLQLMRVPALTDNRTLEIAEISRSLKALAKE
LNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVY
HPDSPLKGTAEIIIGKQRNGPIGSVRLTFQGHYSRFDNYA

Ligand information

• Ligand ID: ALF
• InChI: InChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
• InChIKey: UYOMQIYKOOHAMK-UHFFFAOYSA-J
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: F[Al-](F)(F)F
• Formula: Al F4
• Name: TETRAFLUOROALUMINATE ION
• DrugBank: DB04444
• PDB chain: 6t66 Chain A Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6t66 Study of the DnaB:DciA interplay reveals insights into the primary mode of loading of the bacterial replicative helicase.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): K234 E259 Y341
• Binding residue (residue number reindexed from 1): K213 E238 Y320
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006268 DNA unwinding involved in DNA replication
• GO:0006269 DNA replication, synthesis of primer

Cellular Component

• GO:0005829 cytosol
• GO:1990077 primosome complex

External links

• PDB: RCSB:6t66, PDBe:6t66, PDBj:6t66
• PDBsum: 6t66
• PubMed: 34107018
• UniProt: Q9KUY7