Structure of PDB 6t1b Chain A Binding Site BS02

Receptor Information
>6t1b Chain A (length=271) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDD
RTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFAT
AVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGG
IAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPE
SPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFF
SHRRDRGTTGRMLAFIGRREE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6t1b Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6t1b FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.
Resolution1.2 Å
Binding residue
(original residue number in PDB)		C182 C183 C242 C245
Binding residue
(residue number reindexed from 1)		C181 C182 C241 C244
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
2.4.2.28: S-methyl-5'-thioadenosine phosphorylase.
3.5.4.4: adenosine deaminase.
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0005507 copper ion binding
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
GO:0046872 metal ion binding
GO:0046936 2'-deoxyadenosine deaminase activity

View graph for
Molecular Function
External links
PDB RCSB:6t1b, PDBe:6t1b, PDBj:6t1b
PDBsum6t1b
PubMed31978345
UniProtP84138|PURNU_GEOS3 Purine nucleoside phosphorylase YlmD (Gene Name=ylmD)

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