Structure of PDB 6sqp Chain A Binding Site BS02

Receptor Information
>6sqp Chain A (length=63) Species: 9685 (Felis catus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFPHNAIEPCVICQTRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVC
RQPIQMIVLTYFP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6sqp Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6sqp Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Resolution1.21 Å
Binding residue
(original residue number in PDB)		H452 H457 C475 C478
Binding residue
(residue number reindexed from 1)		H24 H29 C47 C50
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0042802 identical protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6sqp, PDBe:6sqp, PDBj:6sqp
PDBsum6sqp
PubMed32350255
UniProtQ7YRZ8|MDM2_FELCA E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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