Structure of PDB 6sei Chain A Binding Site BS02

Receptor Information

>6sei Chain A (length=276) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QCKPIPALYTVYVLRSTVRHASLYIGSTPNPPRRLKQHNGLVPGGAARTS
RSSLRPWEMVALVSGFPSMVAALKFQWALTNPHLSVHIPSASRRPQRPPR
SLASVVANLHLLLRVPSFARWPLRVHFFRRDVFAAWEKWCAAASERLRPS
LAVVTDFEGGSPCWGIHALPLDYEPIKDYVAKGQEIFEFERQGACVVCRE
EMASGDGLQALCTNQGCDGVGHLSCWSRHFLKEADSILPVQGQCPKCGGE
MEWGNMMKELTLRTRGQKEVEKLLKR

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6sei Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6sei Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease.
Resolution	2.69 Å
Binding residue (original residue number in PDB)	C229 C232 H256 C259
Binding residue (residue number reindexed from 1)	C195 C198 H222 C225
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.1.-.-

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity
GO:0004520	DNA endonuclease activity
GO:0008821	crossover junction DNA endonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006310	DNA recombination

	Cellular Component
GO:0005634	nucleus
GO:0033557	Slx1-Slx4 complex

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External links

PDB	RCSB:6sei, PDBe:6sei, PDBj:6sei
PDBsum	6sei
PubMed	31584081
UniProt	G2QV68

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