Structure of PDB 6se9 Chain A Binding Site BS02

Receptor Information
>6se9 Chain A (length=989) Species: 1492190 (Arthrobacter sp. 32cB) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSLELGAADIQDLESFEAGRGALPARAYLQSDAPRLSLNGEWQFRLSPG
SRVAPDDGWQLGEALNGFESLPVPSSWPMHGHGAPAYTNVQFPFAVEPPH
VPEANPIGDHLVVFEAGPEFFPHALLRFDGIESAGTVWLNGVELGTTRGS
RLAHEFDVSGILEQGENTLAVRVAQFSAASYVEDQDMWWLPGIFRDVTLQ
ARPAAGIDDVFVHAGYDHITGEGILKVEASRGGQAIDAVVRVPELALELA
AGTEVRVPAVEPWSAEVPKLYEAAVSAAGESVALQIGFRSIAIEDAQFKV
NGRRILLRGVNRHEHHPRLGRVVPRDVVEAELRLMKQHNINAIRTSHYPP
HPQFLALADQLGFYVVLECDLETHGFESAGWAQNPSDDPQWEDALVDRMR
RTVERDKNHASVVMWSLGNQAGTGRNLAAMSRWTKDRDPSRPIHYEGDWS
SEHVDVYSRMYASQAETALIGQGIEPALNDAALDARRRAMPFVLCEYVHA
MGNGPGGMSEYQALFEKYPRLMGGFVWEWLEHGITVSTADGVDHYGYGGD
FGEEVHDGNFVTDGLVDADRRPRPGLLDFKKVIEPLRIDVARDWTGFTLR
NGQDFADTSAFSFRYEVEADGGALDGGTVDVAPVAPQSETVVELPGSVAA
LAAGLSDGRPAVLTVRAVLGADSAWADAGHEVAWGQSVREPGAPVPPAPV
EPVQVQDSELTLGPVVFSRATGMPTSIGGVPVEKLGLTLWWAPTDNDLGR
EWGGADERPLATQWKDAGLNRLHTRLLGISANPGQDGGETLTVRTRVSAA
DKQYGVLVDYTWSTDGETVGLRTQVRRDGTWVNRGFEVEWARIGLEFVLG
EETELVSWFGQGPHQSYPDTGQGARAGWFSLPLAKMDVEYVRPQECGARS
GSRSAALQLGGRTLEICGDPFALTVRPYSQDVLDAAAHRPDLKADGRTYL
YVDHALRGVGTAACGPGVLEQYRLKPRDADFILTLKVRS
Ligand information
Ligand IDFRU
InChIInChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
InChIKeyRFSUNEUAIZKAJO-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OC1C(O)C(OC1(O)CO)CO
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
CACTVS 3.341OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)O
CACTVS 3.341OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
FormulaC6 H12 O6
Namebeta-D-fructofuranose;
beta-D-fructose;
D-fructose;
fructose
ChEMBLCHEMBL604608
DrugBank
ZINCZINC000001529270
PDB chain6se9 Chain A Residue 1108 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6se9 Active Site Architecture and Reaction Mechanism Determination of Cold Adapted beta-d-galactosidase fromArthrobactersp. 32cB.
Resolution1.965 Å
Binding residue
(original residue number in PDB)		D230 E249 S251 R458
Binding residue
(residue number reindexed from 1)		D209 E228 S230 R437
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.23: beta-galactosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005990 lactose catabolic process
GO:0009056 catabolic process
Cellular Component
GO:0009341 beta-galactosidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6se9, PDBe:6se9, PDBj:6se9
PDBsum6se9
PubMed31484304
UniProtA0A023UGN9

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