Structure of PDB 6scy Chain A Binding Site BS02

Receptor Information
>6scy Chain A (length=297) Species: 267377 (Methanococcus maripaludis S2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MITMKCRKCGKPSIYHQKHSGNNYCKECFIKETKRKVRKTLGRDVLKNNI
KVAMGLSGGKDSLVMAYLLNEYYKQIPNSNLIAIMVNEGIEGYRTDGIDA
AVKFCEEYGIEYKIVHFKDYLGTNLDEIVKLTMNPCSFCGVIRRKILNRV
SIEEKCDFLAIGHNLDDVAQAVMMNYIEGDVKKLAFLGKSLKHPKFVKRI
KPLEKIPEDEVLLLAEMLELKYHKSPCPYSCLSFRSEVSDITDNLEKNHP
GSKYSIVRGYERLLEHIELECKICGDLSATEVCKVCSYLKNLGILEK
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6scy Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6scy The thiolation of uridine 34 in tRNA, which controls protein translation, depends on a [4Fe-4S] cluster in the archaeum Methanococcus maripaludis.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		E88 R94 C142 C145 R149 C233 S236
Binding residue
(residue number reindexed from 1)		E88 R94 C136 C139 R143 C227 S230
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002143 tRNA wobble position uridine thiolation
GO:0008033 tRNA processing
GO:0034227 tRNA thio-modification
Cellular Component
GO:0002144 cytosolic tRNA wobble base thiouridylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6scy, PDBe:6scy, PDBj:6scy
PDBsum6scy
PubMed37005440
UniProtQ6LXJ4

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