Structure of PDB 6s2e Chain A Binding Site BS02

Receptor Information
>6s2e Chain A (length=1006) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDV
EELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEA
RKLLRPILQDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAF
ADPVVMAFAIATTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISED
IEDFEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDF
FDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSY
LPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVAT
YYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILL
PNKHTDPILESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELP
EALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHV
DVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEF
VSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPS
DKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITC
LTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKL
YLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYK
AMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSD
IFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRS
MSKTLKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAI
PVAIFDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWL
KRKIAT
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6s2e Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6s2e Ctf18-RFC and DNA Pol ε form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		D664 C665 C668 C677 A678 C763 R765
Binding residue
(residue number reindexed from 1)		D575 C576 C579 C588 A589 C612 R614
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6s2e, PDBe:6s2e, PDBj:6s2e
PDBsum6s2e
PubMed32585006
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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