Structure of PDB 6rz4 Chain A Binding Site BS02

Receptor Information

>6rz4 Chain A (length=395) Species: 562,9606

SATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCS
IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM
AKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYT
MIILTLLKKSMKSADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAA
LDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEA
QAAAEQLKTTRNAYIQKYLLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTI
HLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG

Ligand information

• Ligand ID: NA
• InChI: InChI=1S/Na/q+1
• InChIKey: FKNQFGJONOIPTF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Na+]
• Formula: Na
• Name: SODIUM ION
• DrugBank: DB14516
• PDB chain: 6rz4 Chain A Residue 2002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rz4 Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): D69 S110 N287 C288 D291
• Binding residue (residue number reindexed from 1): D59 S100 N382 C383 D386
• Annotation score: 3

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004974 leukotriene receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0022900 electron transport chain

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:6rz4, PDBe:6rz4, PDBj:6rz4
• PDBsum: 6rz4
• PubMed: 31633023
• UniProt: P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
  Q9Y271