Structure of PDB 6ry2 Chain A Binding Site BS02

Receptor Information

>6ry2 Chain A (length=410) Species: 759272 (Thermochaetoides thermophila DSM 1495)

QYYKIDTKEEILESARTLAYDMMLFYKGNQSGEIPGILPGPPTEHKGDYY
WWEGGAMMGTYVDYWHLTGDPSYNHVIMEGMLHQVGPNADYQPPNHTASL
GNDDQGFWGMSAMLAAENKFPNPPDDKPQWLALAQAVWTTQASPERHDGT
CNGGLRWQIPPTNAGYNYKNTIANACFFDLGARLARYTKNNTYAEWAEKI
FDWLYAVGYIDHETWAVYDGGHVEHNCTDINRAQFSYNAALLLHGAAFMW
NYTEDQKWKDRVDNLLTGILRDFFKDGVVFEIPCEGRQGACTADMLTFKG
YVHRWMAVVTQIAPHTKDRILPVLRTSAEAAVKQCVGPPTGRRCGFYWKS
GKFVDPSVDHTSGAGEAMSVLAAVSSLLIEYAEPPATNETGISRGDPNAG
MRSRGAAQHF

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6ry2 Chain A Residue 703

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ry2 Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls.
• Resolution: 1.3 Å
• Binding residue (original residue number in PDB): S130 D135
• Binding residue (residue number reindexed from 1): S99 D104
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.101: mannan endo-1,6-alpha-mannosidase.

Gene Ontology

Molecular Function

• GO:0008496 mannan endo-1,6-alpha-mannosidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0009272 fungal-type cell wall biogenesis
• GO:0016052 carbohydrate catabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6ry2, PDBe:6ry2, PDBj:6ry2
• PDBsum: 6ry2
• PubMed: 32839341
• UniProt: G0S3F2