Structure of PDB 6rxr Chain A Binding Site BS02

Receptor Information
>6rxr Chain A (length=224) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPPLRPHVVWFGEMPLGMDEI
YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF
AEKYYGPASQVVPEFVEKLLKGLK
Ligand information
>6rxr Chain F (length=10) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGAKRHRKIL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rxr Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		E73 E79 R83 G191
Binding residue
(residue number reindexed from 1)		E34 E40 R44 G141
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxr, PDBe:6rxr, PDBj:6rxr
PDBsum6rxr
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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