Structure of PDB 6rwn Chain A Binding Site BS02

Receptor Information
>6rwn Chain A (length=270) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFLDGIEKAQEEHEKYHNNWRAMAEDFQIPQVVAKEIVAQCPKCQVKGEA
MHGQVDASPKTWQMDCTHLEGKVIIVAVHVASGYIEAEVLPAETGKETAH
FLLKLAARWPVKHLHTDNGDNFTSSAVQAVCWWAQIEHTFGVPYNPQSQG
VVESMNHQLKTIITQIRDQAEKIETAVQMAVLIHNFKRKGGIGGYSAGER
IIDIIASDLQTTKLQNQISKIQNFRVYFREGRDQQWKGPATLIWKGEGAV
VIQDGQDLKVVPRRKCKIIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6rwn Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E152 H156
Binding residue
(residue number reindexed from 1)		E153 H157
Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6rwn, PDBe:6rwn, PDBj:6rwn
PDBsum6rwn
PubMed32001525
UniProtE1ANT8

[Back to BioLiP]