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Receptor Information

>6rvz Chain A (length=346) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GVIKRNWEYINKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFP
NILKEIKHFDADVLCLQEVQEDHYGAEIRPSLESLGYHCEYKMRTGRKPD
GCAICFKHSKFSLLSVNPVEFFRPDISLLDRDNVGLVLLLQPKIPCPAIC
VANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCPIVMCGDFNSV
PGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRILSIPIWPPNLGISQ
NCVYEVQQVPSSNLQHHFSLSSVYSHYFPDTGIPEVTTCHSRSAITVDYI
FYSAGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL

Ligand ID

ADN

InChI

InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

InChIKey

OIRDTQYFTABQOQ-KQYNXXCUSA-N

SMILES

Software	SMILES
CACTVS 3.341	Nc1ncnc2n(cnc12)[CH]3O[CH](CO)[CH](O)[CH]3O
ACDLabs 10.04	n2c1c(ncnc1n(c2)C3OC(C(O)C3O)CO)N
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N
CACTVS 3.341	Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CO)O)O)N

Formula

C10 H13 N5 O4

Name

ADENOSINE

PDB chain

6rvz Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6rvz ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	S472 W519
Binding residue (residue number reindexed from 1)	S291 W321
Annotation score	4

Enzyme Commision number

	Molecular Function
GO:0003824	catalytic activity

PDB	RCSB:6rvz, PDBe:6rvz, PDBj:6rvz
PDBsum	6rvz
PubMed	32732418
UniProt	Q5VTE6\|ANGE2_HUMAN Protein angel homolog 2 (Gene Name=ANGEL2)

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Structure of PDB 6rvz Chain A Binding Site BS02