Structure of PDB 6rv3 Chain A Binding Site BS02

Receptor Information
>6rv3 Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRA
RYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAA
PSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGAD
VSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFG
DYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAED
EKRDAENL
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain6rv3 Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6rv3 A lower X-gate in TASK channels traps inhibitors within the vestibule.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		T93 I94 G95 T199 I200 G201
Binding residue
(residue number reindexed from 1)		T93 I94 G95 T196 I197 G198
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005252 open rectifier potassium channel activity
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rv3, PDBe:6rv3, PDBj:6rv3
PDBsum6rv3
PubMed32499642
UniProtO14649|KCNK3_HUMAN Potassium channel subfamily K member 3 (Gene Name=KCNK3)

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