Structure of PDB 6rku Chain A Binding Site BS02

Receptor Information
>6rku Chain A (length=511) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGN
DWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQG
NFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPD
VMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEG
LMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRE
TIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEV
KRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRH
RREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAK
TALVANPWQLGNVAAAGDDAARPEWLEPEFGVGLYYLTEQQAQAILDLRL
QKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQF
GDKRRTEITAN
Ligand information
Receptor-Ligand Complex Structure
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PDB6rku Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		I174 V176 K239
Binding residue
(residue number reindexed from 1)		I167 V169 K232
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0034335 DNA negative supercoiling activity
GO:0042802 identical protein binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006351 DNA-templated transcription
GO:0009410 response to xenobiotic stimulus
GO:0046677 response to antibiotic
GO:0051276 chromosome organization
GO:2000104 negative regulation of DNA-templated DNA replication
Cellular Component
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rku, PDBe:6rku, PDBj:6rku
PDBsum6rku
PubMed31666516
UniProtP0AES4|GYRA_ECOLI DNA gyrase subunit A (Gene Name=gyrA)

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