Structure of PDB 6rie Chain A Binding Site BS02

Receptor Information

>6rie Chain A (length=1285) Species: 10245 (Vaccinia virus)

AVISKVTYSLYDQKEINATDIIISHVKNDDDIGTVKDGRLGAMDGALCKT
CGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNHICIHCGLLRSREP
YSDDINLKELSGHALRRLKDKILSKKKSCWNSECMQPYQKITFSKKKVCF
VNKLDDINVPNSLIYQKLISIHEKFWPLLEIHQYPANLFYTDYFPIPPLI
IRPAISFWIDSIPKETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIK
IISNNTTSINLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEV
GMPAYIRNTLTEKIFVNAFTVDKVKQLLASNQVKFYFNKRLNQLTRIRQG
KFIKNKIHLLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDT
IKISPGIANSQNADFDGDEEWMILEQNPKAVIEQSILMYPTTLLKHDIHG
APVYGSIQDEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGK
DIYTYLIGEKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSN
VEGINFIIKSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIEL
IKEAYAKYLNDVRDGKIVPLSKALEADYVESMLSNLTNLNIREIEEHMRQ
TLIDDPDNNLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRV
LPYYLPDSKDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSR
TGTLARKIIKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLI
YPDESMTWYLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTE
DNAIKVKDLYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRIT
KETAITIFEKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEK
SGAVKQKLGFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLG
ELNPNITLRKETDKYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIV
KEWGMETFIEDEDNIRFTVYLNFVEPEELNLSKFMMVLPGAANKGKISKF
KIPISDYTGYDDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTY
DIFGIEAAREYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKF
KFGAASTLKRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGY
YKYFIDLGLLMRMERKLSDKISSQKIKEMEETEDF

Ligand information

>6rie Chain P (length=16)

gaguaaaugucauugg

................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rie Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): S207 F208 Q381 D419
• Binding residue (residue number reindexed from 1): S206 F207 Q380 D418

Enzymatic activity

• Enzyme Commision number: 2.7.7.6: DNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003899 DNA-directed 5'-3' RNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0034062 5'-3' RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex
• GO:0044423 virion component

External links

• PDB: RCSB:6rie, PDBe:6rie, PDBj:6rie
• PDBsum: 6rie
• PubMed: 31835031
• UniProt: O57204|RP147_VACCA DNA-directed RNA polymerase 147 kDa polypeptide (Gene Name=OPG105)