Structure of PDB 6r7w Chain A Binding Site BS02

Receptor Information
>6r7w Chain A (length=270) Species: 28112 (Tannerella forsythia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSSTILIPVVVHVVYNNSAQNISDAQIISQIQVLNEDFRRMNADQANTPS
AFANLAGNANIEFKLARRDPNGNTTNGITRTSTSTETFSMEMDNVKFSNL
GGNNAWNTRRYLNIWVCNLGDDLLGYAQFPFEFQTKPNTDGVVIHYKHFG
RDGSAESPYDKGRTATHEVGHWLDLRHIWGDDGGSCSGTDNIADTPNQGG
YNEGCPSFPKTDHCTNTSPGVMFMNYMDYTYDACMNLFTKGQVERMRSLF
DTQTGIRREMQIYANELTNP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6r7w Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6r7w Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		W236 D239 S242 Q255 G256
Binding residue
(residue number reindexed from 1)		W179 D182 S185 Q198 G199
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:6r7w, PDBe:6r7w, PDBj:6r7w
PDBsum6r7w
PubMed31949901
UniProtG8ULV1

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