Structure of PDB 6qzi Chain A Binding Site BS02

Receptor Information
>6qzi Chain A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGV
HVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYS
LFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGML
QLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLP
PRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGST
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain6qzi Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6qzi Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		F74 G222 Y223 A224 R229
Binding residue
(residue number reindexed from 1)		F42 G190 Y191 A192 R197
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015267 channel activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6qzi, PDBe:6qzi, PDBj:6qzi
PDBsum6qzi
PubMed31831212
UniProtO14520|AQP7_HUMAN Aquaporin-7 (Gene Name=AQP7)

[Back to BioLiP]