Structure of PDB 6pz3 Chain A Binding Site BS02

Receptor Information
>6pz3 Chain A (length=429) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAA
IERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIR
KIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCR
GIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLT
KDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVI
KNMNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6pz3 Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Resolution2.395 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 G46 I47 I48 S62 W64 K86 R93 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351
Binding residue
(residue number reindexed from 1)		Q38 Y39 W42 G46 I47 I48 S62 W64 K86 R93 K308 R310 P313 K314 T315 G317 S319 K320 N321 P323 G324 R348
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6pz3, PDBe:6pz3, PDBj:6pz3
PDBsum6pz3
PubMed31704958
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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